Semax

Peptide Name: Semax 
 
RESEARCHED AREAS AND BENEFITS
Neuroprotective gene expression modulation
BDNF upregulation cognitive support
Ischemic stroke recovery acceleration
Dopaminergic system motivation enhancement
Neuroinflammation reduction protective effects
 
Chemical Name: L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline
CAS Number: 80714-61-0
 
DESCRIPTION 
Semax is a synthetic heptapeptide analogue of a fragment of the adrenocorticotropic hormone (ACTH 4-10). It was originally developed by the Institute of Molecular Genetics of the Russian Academy of Sciences to provide powerful neuroprotective and nootropic benefits without the systemic hormonal side effects typically associated with ACTH. The peptide is structured with a Pro-Gly-Pro tripeptide sequence at its C-terminus, which protects it from rapid enzymatic degradation in the bloodstream. In research, Semax is primarily studied for its ability to cross the blood-brain barrier and rapidly influence the central nervous system, where it modulates the expression of over 50 genes related to neuronal survival and inflammatory responses.
 
Neurotrophic Support: Research shows it significantly increases levels of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF), which are critical for neuroplasticity and memory formation.
Cerebrovascular Recovery: Clinical studies in stroke patients suggest it can reduce the size of brain lesions (infarcts) and improve the recovery of motor and cognitive functions.
Mental Performance: Investigations indicate that it enhances focus, attention, and executive function by balancing dopamine and serotonin levels without stimulant-like crashes.
TBI Rehabilitation: Recent 2025-2026 studies have focused on its potential to accelerate recovery from traumatic brain injuries (TBI) by reducing secondary oxidative damage and neuroinflammation.
 
KIT INCLUDES:
1x Peptide Vial
1x 10ml Sterile Water
1x Reconstitution Kit
 
REGULATORY NOTICES
SAHPRA DISCLAIMER This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA). It is not intended to diagnose, treat, cure, or prevent any disease.
RESEARCH USE ONLY
Semax as a Universal Drug for Therapy and Research (2026 Review): https://www.researchgate.net/publication/331676637_Semax_as_a_Universal_Drug_for_Therapy_and_Research
The Potential of the Peptide Drug Semax for Correcting Alzheimer's Pathologies: https://pmc.ncbi.nlm.nih.gov/articles/PMC12755871/
Semax Suppresses Proinflammatory Mediators Induced by Reversible Ischemia: https://pubmed.ncbi.nlm.nih.gov/34005822/
Clinical Study on Semax Efficacy in the Treatment of Ischemic Stroke: https://pubmed.ncbi.nlm.nih.gov/9385315/