Selank

PRODUCT DESCRIPTION
Peptide Name: Selank
 
RESEARCHED AREAS AND BENEFITS
Anxiolytic effects without sedation
GABAergic system allosteric modulation
BDNF upregulation cognitive support
Enkephalin degradation enzyme inhibition
Immunomodulatory cytokine profile normalization
 
Chemical Name: L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline
CAS Number: 129954-34-3
 
DESCRIPTION
Selank is a synthetic heptapeptide analogue of the naturally occurring immunomodulatory tetrapeptide tuftsin. Developed by the Institute of Molecular Genetics of the Russian Academy of Sciences, it was designed to combine the immune-boosting properties of tuftsin with a Pro-Gly-Pro tripeptide sequence at its C-terminus to enhance metabolic stability. Research focuses on its unique "anxiolytic-nootropic" profile, where it appears to reduce anxiety and emotional stress while simultaneously improving executive functions such as learning and memory. Unlike traditional benzodiazepines, Selank is studied for its ability to provide these effects without causing muscle relaxation, withdrawal, or sedative-hypnotic side effects.
 
Neurotransmitter Modulation: Research indicates it influences the concentration of monoamine neurotransmitters (serotonin, dopamine, and norepinephrine) and affects the expression of genes involved in GABAergic neurotransmission.
Nootropic Properties: Studies suggest Selank rapidly elevates the expression of Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus, which is vital for synaptic plasticity.
Antidepressant Effects: Animal models have shown that the peptide can reduce manifestations of anhedonia and improve behavior in chronic stress environments.
Metabolic and Immune Support: Investigations have explored its role in regulating cytokine balances (such as IL-6) and its potential impact on lipid profiles in metabolic syndrome models.
 
KIT INCLUDES:
1x Peptide Vial
1x 10ml Sterile Water
1x Reconstitution Kit
 
REGULATORY NOTICES
SAHPRA DISCLAIMER This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA). It is not intended to diagnose, treat, cure, or prevent any disease.
RESEARCH USE ONLY
 
SCIENTIFIC STUDIES
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission: https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/
GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00089/full
Regenerative and Protective Actions of Peptides Based on Natural Regulatory Peptides: https://pdfs.semanticscholar.org/2a11/334f12fff603f90a83ef1127e3192ca186b2.pdf
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Chronic Stress Conditions: https://pmc.ncbi.nlm.nih.gov/articles/PMC5322660/