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MOTS-c

MOTS-c

From R585,00Price
mg
10
40
Quantity
PRODUCT DESCRIPTION
Peptide Name: MOTS-c 
 
RESEARCHED AREAS AND BENEFITS
  • Metabolic homeostasis energy regulation
  • Insulin sensitivity glucose uptake
  • Mitochondrial biogenesis cellular health
  • Exercise mimetic physical performance
  • Weight management fat oxidation
 
Chemical Name: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
CAS Number: 1627580-64-6
 
DESCRIPTION
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a 16-amino acid peptide encoded by the mitochondrial genome rather than the nuclear genome. It functions as a "mitokine" or retrograde signaling molecule that communicates between the mitochondria and the nucleus to regulate metabolic adaptation. Originally discovered in 2015, research has focused on its ability to translocate to the nucleus under metabolic stress to activate gene expression related to antioxidant responses and energy metabolism. It is widely studied for its potential to mimic the beneficial effects of exercise on a cellular level, making it a primary candidate for research into metabolic disorders and age-related physiological decline.
 
  • Metabolic Regulation: Research indicates it activates the AMPK pathway, which is the body's master metabolic switch for energy production and fat burning.
  • Insulin Sensitivity: Studies show that MOTS-c can significantly improve glucose handling and reduce insulin resistance in high-fat diet models.
  • Physical Performance: Data suggests exogenous administration can enhance running capacity and motor coordination by increasing mitochondrial efficiency in skeletal muscle.
  • Anti-Aging Potential: Investigations have observed that systemic MOTS-c levels naturally decline with age, and restoring these levels may counteract age-dependent metabolic dysfunction.
 
KIT INCLUDES:
1x Peptide Vial
1x 10ml Sterile Water
1x Reconstitution Kit
 
REGULATORY NOTICES
SAHPRA DISCLAIMER This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA). It is not intended to diagnose, treat, cure, or prevent any disease.
RESEARCH USE ONLY 
 
SCIENTIFIC STUDIES
  • MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging: https://pmc.ncbi.nlm.nih.gov/articles/PMC9570330/
  • The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis: https://pubmed.ncbi.nlm.nih.gov/25738892/
  • MOTS-c restores mitochondrial respiration in type 2 diabetic heart: https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1602271/full
  • MOTS-c reduces myostatin and muscle atrophy signaling: https://journals.physiology.org/doi/abs/10.1152/ajpendo.00275.2020

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