PT-141
Peptide Name: PT-141 (Bremelanotide)
CAS Number: 189691-06-3 (Free Base) / 1607799-13-2 (Acetate)
General Overview
PT-141 is a synthetic peptide analogue of the naturally occurring $\alpha\text{-Melanocyte Stimulating Hormone}$ ($\alpha\text{-MSH}$). Unlike traditional treatments for sexual dysfunction that target the vascular system (blood flow), PT-141 is unique because it acts directly on the central nervous system. By binding to and activating melanocortin receptors in the brain—specifically the MC3R and MC4R subtypes—it triggers internal pathways associated with sexual motivation and desire.
Researched Benefits
Neurological Activation: Research indicates that PT-141 bypasses the cardiovascular system to initiate arousal through hypothalamic stimulation.
Treatment of HSDD: Extensively studied for Hypoactive Sexual Desire Disorder (HSDD) in premenopausal women, showing significant increases in satisfying sexual events.
Support for ED: In clinical trials, it has shown efficacy in men with erectile dysfunction, including those who did not respond to PDE5 inhibitors like sildenafil.
Rapid Onset: Studies have noted physiological responses often occurring within 30 minutes to 2 hours post-administration.
Broad Application: Investigated for its potential to improve mood and general well-being tied to sexual health.
KIT INCLUDES:
1x Peptide Vial
1x 10ml Sterile Water
1x Reconstitution Kit
Disclaimers
SAHPRA DISCLAIMER: This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA). This product is not intended to diagnose, treat, cure, or prevent any disease.
RESEARCH USE ONLY
Research Studies and References
Long-Term Safety and Efficacy of Bremelanotide (2019): https://pubmed.ncbi.nlm.nih.gov/31599847/
Bremelanotide for the Treatment of HSDD: Phase 3 Trials (2019): https://pmc.ncbi.nlm.nih.gov/articles/PMC6819021/
Melanocortin Receptors and Penile Erection Research: https://pmc.ncbi.nlm.nih.gov/articles/PMC2694735/
PT-141: A Melanocortin Agonist for Sexual Dysfunction: https://pubmed.ncbi.nlm.nih.gov/12851303/
