5-Amino-1MQ
Peptide/Compound Name: 5-Amino-1MQ (5-Amino-1-methylquinolinium)
CAS Number: 42464-96-0 (Iodide) / 1190315-88-7 (Free Cation)
General Overview
5-Amino-1MQ is a cell-permeable, small molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). While often categorized in the "peptide therapy" space due to its metabolic signaling properties, it is technically a quinolinium derivative. Research focuses on its ability to block NNMT, an enzyme that is frequently overexpressed in white adipose tissue in cases of obesity and type 2 diabetes. By inhibiting this enzyme, 5-Amino-1MQ alters the metabolic "programming" of cells, shifting them from a state of fat storage to a state of active energy expenditure and fat oxidation.
Researched Benefits
Selective Fat Loss: Clinical models have demonstrated that 5-Amino-1MQ can reduce body weight and white adipose tissue mass by up to 7% in short-duration studies without decreasing food intake.
NAD+ Optimization: By preventing the methylation of nicotinamide (NAM), the compound allows for a higher conversion rate of NAM into NAD+, which is critical for mitochondrial efficiency and DNA repair.
Anti-Aging and SIRT1: Increased levels of NAD+ secondary to NNMT inhibition lead to the activation of SIRT1, the "longevity gene," which is associated with reduced risk of cardiovascular and neurodegenerative diseases.
Muscle Preservation: Unlike many weight-loss interventions, research into 5-Amino-1MQ shows it may promote myoblast (muscle cell) differentiation and repair, helping to maintain lean mass during fat loss.
Improved Insulin Sensitivity: Studies suggest the compound helps normalize blood glucose levels and improves systemic insulin response, making it a subject of interest for type 2 diabetes research.
KIT INCLUDES:
1x Peptide Vial
1x 10ml Sterile Water
1x Reconstitution Kit
Disclaimers
SAHPRA DISCLAIMER: This product has not been evaluated by the South African Health Products Regulatory Authority (SAHPRA). This product is not intended to diagnose, treat, cure, or prevent any disease.
RESEARCH USE ONLY: This compound is strictly for research and development purposes only.
Research Studies and References
Selective NNMT Inhibitors Reverse Diet-Induced Obesity (2018): https://pmc.ncbi.nlm.nih.gov/articles/PMC5826726/
Roles of NNMT in Obesity and Type 2 Diabetes (2024 Review): https://pmc.ncbi.nlm.nih.gov/articles/PMC8337113/
NNMT Inhibition as a Strategy for Muscle Regeneration: https://www.chemicalbook.com/ChemicalProductProperty_EN_CB05839892.htm
Nicotinamide N-methyltransferase: A Novel Target for Metabolic Syndrome (2026): https://pmc.ncbi.nlm.nih.gov/articles/PMC11196770/
5-Amino-1MQ and its Effect on SIRT1 Activation: https://focalpointvitality.com/5-amino-1-peptide/
