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FOR RESEARCH PURPOSES ONLY. All information provided within the Biolabs Peptides Research Centre is intended strictly for scientific, laboratory, and educational purposes.

Not Medical Advice: The protocols and data presented herein do not constitute medical advice, nursing advice, or a professional healthcare diagnosis.
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SLU-PP-332
5MG

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HIGHLIGHTS

SLU-PP-332 is a pioneering synthetic small-molecule agonist of the Estrogen-Related Receptors (ERRα, ERRβ, and ERRγ). Often referred to in literature as an "exercise mimetic," it is researched for its unique ability to reprogram cellular metabolism to mimic the effects of endurance training. By activating the ERR pathway, it enhances mitochondrial biogenesis and shifts fuel preference toward fat oxidation, offering a non-stimulant approach to investigating metabolic flexibility and obesity.

Observed Benefits

Exercise Mimetic Response: Induces gene expression patterns in skeletal muscle typically only seen after acute aerobic exercise.
Metabolic Reprogramming: Promotes "fat as fuel" by increasing fatty acid oxidation and reducing lipid storage.
Mitochondrial Biogenesis: Observed to significantly increase mitochondrial DNA content and cellular respiration efficiency.
Insulin Sensitivity: Demonstrated in mouse models to improve glucose homeostasis and insulin response without altering food intake.
Endurance Support: Potential to increase running distance and grip strength in research models by sparing glycogen stores.

Protocol Overview

Research involving SLU-PP-332 often utilizes subcutaneous administration to bypass first-pass metabolism, though it is also studied via oral routes in specific laboratory settings. For a 5mg vial, a common reconstitution uses 1.0 mL to 2.0 mL of Bacteriostatic Water. Given its potency as an ERR agonist, research doses are typically measured in micrograms (mcg) to observe incremental changes in energy expenditure.

Research Protocol Dosing

Standard Daily Research Dose: 250 mcg – 500 mcg (0.25 mg – 0.5 mg) — Injected once daily or split into two doses.

Concentrated Reconstitution (1 mL per 5mg vial): 5 units on a U-100 syringe = 250 mcg.

Frequency: Research is typically conducted daily for 4–8 weeks to observe shifts in body composition and mitochondrial density.

Pre-Training (Optional): In athletic research models, a dose is often administered 30 minutes prior to a training session to maximize fatty acid utilization.

Supplies Needed

Step-by-Step: How to Reconstitute SLU-PP-332
Sanitize Everything: Clean your workspace and wear gloves.
Open the Vial: Remove the cap and wipe the rubber stopper with an alcohol swab.
How to mix - 5mg vial of SLU; add 0.5ml (50units) DMSO, add slowly and gently swirl until dissolved. Next, put 2ml of BAC in a separate vial. Next, add DROP by DROP very slowly into the side of the vial of BAC water (2 to 3 drops and swirl, repeat) – This makes 2,000mcg/ml – the dose is 10 units that = 200mcg dose – Store in Refrigerator
Sourcing Sterile, Pharmaceutical-Grade Solvents
DMSO: Only use DMSO that is labeled as sterile and pharmaceutical grade. Reputable suppliers include Medisca, Sigma-Aldrich, and Fisher Scientific. Always request a Certificate of Analysis (COA) and sterility documentation.
PEG-400: The same rules apply—only source from trusted suppliers, and never use industrial or technical grade for research involving biological systems.

Storage

Pre-reconstitution (Lyophilized Powder): Store frozen at -20°C (-4°F) for long-term stability (up to 3 years). Protect from light.
Post-reconstitution (Liquid Solution): Refrigerate at 2–8°C (36–46°F). Use within 30 days for maximum integrity. Avoid repeated freeze-thaw cycles.